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Cryo-EM and MD infer water-mediated proton transport and autoinhibition mechanisms of V(o) complex
Rotary vacuolar adenosine triphosphatases (V-ATPases) drive transmembrane proton transport through a V(o) proton channel subcomplex. Despite recent high-resolution structures of several rotary ATPases, the dynamic mechanism of proton pumping remains elusive. Here, we determined a 2.7-Å cryo–electron...
Shranjeno v:
| izdano v: | Sci Adv |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Association for the Advancement of Science
2020
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7541076/ https://ncbi.nlm.nih.gov/pubmed/33028525 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abb9605 |
| Oznake: |
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