Cryo-EM and MD infer water-mediated proton transport and autoinhibition mechanisms of V(o) complex

Rotary vacuolar adenosine triphosphatases (V-ATPases) drive transmembrane proton transport through a V(o) proton channel subcomplex. Despite recent high-resolution structures of several rotary ATPases, the dynamic mechanism of proton pumping remains elusive. Here, we determined a 2.7-Å cryo–electron...

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Veröffentlicht in:Sci Adv
Hauptverfasser: Roh, Soung-Hun, Shekhar, Mrinal, Pintilie, Grigore, Chipot, Christophe, Wilkens, Stephan, Singharoy, Abhishek, Chiu, Wah
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Association for the Advancement of Science 2020
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Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7541076/
https://ncbi.nlm.nih.gov/pubmed/33028525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abb9605
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