Integrating Systems Biology and an Ex Vivo Human Tumor Model Elucidates PD-1 Blockade Response Dynamics

Ex vivo human tumor models have emerged as promising, yet complex tools to study cancer immunotherapy response dynamics. Here, we present a strategy that integrates empirical data from an ex vivo human system with computational models to interpret the response dynamics of a clinically prescribed PD-...

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Publicado no:iScience
Main Authors: Smalley, Munisha, Przedborski, Michelle, Thiyagarajan, Saravanan, Pellowe, Moriah, Verma, Amit, Brijwani, Nilesh, Datta, Debika, Jain, Misti, Shanthappa, Basavaraja U., Kapoor, Vidushi, Gopinath, Kodaganur S., Doval, D.C., Sabitha, K.S., Taroncher-Oldenburg, Gaspar, Majumder, Biswanath, Majumder, Pradip, Kohandel, Mohammad, Goldman, Aaron
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7303667/
https://ncbi.nlm.nih.gov/pubmed/32554190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101229
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