Targeting Tumor Phenotypic Plasticity and Metabolic Remodeling in Adaptive Cross-Drug Tolerance

Metastable phenotypic state transitions in cancer cells can lead to the development of transient adaptive resistance or tolerance to chemotherapy. Here, we report that the acquisition of a phenotype marked by increased abundance of CD44 (CD44(Hi)) by breast cancer cells as a tolerance response to ro...

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Detalhes bibliográficos
Publicado no:Sci Signal
Main Authors: Goldman, Aaron, Khiste, Sachin, Freinkman, Elizaveta, Dhawan, Andrew, Majumder, Biswanath, Mondal, Jayanta, Pinkerton, Anthony B., Eton, Elliot, Medhi, Ragini, Chandrasekar, Vineethkrishna, Rahman, M. Mamunur, Ichimura, Takaharu, Gopinath, Kodaganur S., Majumder, Pradip, Kohandel, Mohammad, Sengupta, Shiladitya
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7261372/
https://ncbi.nlm.nih.gov/pubmed/31431543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aas8779
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