Rationally co-targeting divergent pathways in KRAS wild-type colorectal cancers by CANscript technology reveals tumor dependence on Notch and Erbb2

KRAS mutation status can distinguish between metastatic colorectal carcinoma (mCRC) patients who may benefit from therapies that target the epidermal growth factor receptor (EGFR), such as cetuximab. However, patients whose tumors harbor mutant KRAS (codons 12/13, 61 and 146) are often excluded from...

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Foilsithe in:Sci Rep
Main Authors: Brijwani, Nilesh, Jain, Misti, Dhandapani, Muthu, Zahed, Farrah, Mukhopadhyay, Pragnashree, Biswas, Manjusha, Khatri, Deepak, Radhakrishna, Vinod D., Majumder, Biswanath, Radhakrishnan, Padhma, Thiyagarajan, Saravanan
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group UK 2017
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5431418/
https://ncbi.nlm.nih.gov/pubmed/28473715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-01566-x
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