The ERBB network facilitates KRAS-driven lung tumorigenesis

KRAS is the most frequently mutated driver oncogene in human adenocarcinoma of the lung. There are presently no clinically proven strategies for treatment of KRAS-driven lung cancer. Activating mutations in KRAS are thought to confer independence from upstream signaling, however recent data suggest...

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Detalhes bibliográficos
Publicado no:Sci Transl Med
Main Authors: Kruspig, Björn, Monteverde, Tiziana, Neidler, Sarah, Hock, Andreas, Kerr, Emma, Nixon, Colin, Clark, William, Hedley, Ann, Laing, Sarah, Coffelt, Seth B., Quesne, John Le, Dick, Craig, Vousden, Karen, Martins, Carla P., Murphy, Daniel J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6881183/
https://ncbi.nlm.nih.gov/pubmed/29925636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aao2565
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