Mitochondrial superoxide contributes to oxidative stress exacerbated by DNA damage response in RAD51-depleted ovarian cancer cells

Ovarian cancer is the most lethal gynecological malignancy. Abnormal homologous recombination repair, high level of reactive oxygen species (ROS) and upregulation of antioxidant genes are characteristic features of ovarian cancer. However, the molecular mechanisms governing the redox homeostasis in...

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Veröffentlicht in:Redox Biol
Hauptverfasser: Xu, Limei, Wu, Tingting, Lu, Shihua, Hao, Xiaohe, Qin, Junchao, Wang, Jing, Zhang, Xiyu, Liu, Qiao, Kong, Beihua, Gong, Yaoqin, Liu, Zhaojian, Shao, Changshun
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2020
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7303666/
https://ncbi.nlm.nih.gov/pubmed/32554304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2020.101604
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