Berberine induces oxidative DNA damage and impairs homologous recombination repair in ovarian cancer cells to confer increased sensitivity to PARP inhibition

Many cancer drugs exert their therapeutic effect by inducing oxidative stress in the cancer cells. Oxidative stress compromises cell survival by inflicting lesions in macromolecules like DNA. Cancer cells rely on enhanced antioxidant metabolism and increased DNA repair function to survive oxidative...

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Dades bibliogràfiques
Publicat a:Cell Death Dis
Autors principals: Hou, Dong, Xu, Guangwei, Zhang, Caibo, Li, Boxuan, Qin, Junchao, Hao, Xiaohe, Liu, Qiao, Zhang, Xiyu, Liu, Jinsong, Wei, Jianjun, Gong, Yaoqin, Liu, Zhaojian, Shao, Changshun
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2017
Matèries:
Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5680592/
https://ncbi.nlm.nih.gov/pubmed/28981112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.471
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