Berberine induces oxidative DNA damage and impairs homologous recombination repair in ovarian cancer cells to confer increased sensitivity to PARP inhibition

Many cancer drugs exert their therapeutic effect by inducing oxidative stress in the cancer cells. Oxidative stress compromises cell survival by inflicting lesions in macromolecules like DNA. Cancer cells rely on enhanced antioxidant metabolism and increased DNA repair function to survive oxidative...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Izdano u:Cell Death Dis
Glavni autori: Hou, Dong, Xu, Guangwei, Zhang, Caibo, Li, Boxuan, Qin, Junchao, Hao, Xiaohe, Liu, Qiao, Zhang, Xiyu, Liu, Jinsong, Wei, Jianjun, Gong, Yaoqin, Liu, Zhaojian, Shao, Changshun
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2017
Teme:
Original Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5680592/
https://ncbi.nlm.nih.gov/pubmed/28981112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.471
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items