Berberine induces oxidative DNA damage and impairs homologous recombination repair in ovarian cancer cells to confer increased sensitivity to PARP inhibition

Many cancer drugs exert their therapeutic effect by inducing oxidative stress in the cancer cells. Oxidative stress compromises cell survival by inflicting lesions in macromolecules like DNA. Cancer cells rely on enhanced antioxidant metabolism and increased DNA repair function to survive oxidative...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cell Death Dis
Egile Nagusiak: Hou, Dong, Xu, Guangwei, Zhang, Caibo, Li, Boxuan, Qin, Junchao, Hao, Xiaohe, Liu, Qiao, Zhang, Xiyu, Liu, Jinsong, Wei, Jianjun, Gong, Yaoqin, Liu, Zhaojian, Shao, Changshun
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2017
Gaiak:
Original Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5680592/
https://ncbi.nlm.nih.gov/pubmed/28981112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.471
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