Berberine induces oxidative DNA damage and impairs homologous recombination repair in ovarian cancer cells to confer increased sensitivity to PARP inhibition

Many cancer drugs exert their therapeutic effect by inducing oxidative stress in the cancer cells. Oxidative stress compromises cell survival by inflicting lesions in macromolecules like DNA. Cancer cells rely on enhanced antioxidant metabolism and increased DNA repair function to survive oxidative...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Hou, Dong, Xu, Guangwei, Zhang, Caibo, Li, Boxuan, Qin, Junchao, Hao, Xiaohe, Liu, Qiao, Zhang, Xiyu, Liu, Jinsong, Wei, Jianjun, Gong, Yaoqin, Liu, Zhaojian, Shao, Changshun
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5680592/
https://ncbi.nlm.nih.gov/pubmed/28981112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.471
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