T cell-inducing vaccine durably prevents mucosal SHIV infection even with lower neutralizing antibody titers

Recent efforts toward an HIV vaccine focus on inducing broadly neutralizing antibodies, but eliciting both neutralizing antibodies (nAbs) and cellular responses may be superior. Here, we immunized macaques with an HIV envelope trimer, either alone to induce nAbs, or together with a heterologous vira...

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Gepubliceerd in:Nat Med
Hoofdauteurs: Arunachalam, Prabhu S., Charles, Tysheena P., Joag, Vineet, Bollimpelli, Venkata S., Scott, Madeleine K. D., Wimmers, Florian, Burton, Samantha L., Labranche, Celia C., Petitdemange, Caroline, Gangadhara, Sailaja, Styles, Tiffany M., Quarnstrom, Clare F., Walter, Korey A., Ketas, Thomas J., Legere, Traci, Jagadeesh Reddy, Pradeep Babu, Kasturi, Sudhir Pai, Tsai, Anthony, Yeung, Bertrand Z., Gupta, Shakti, Tomai, Mark, Vasilakos, John, Shaw, George M., Kang, Chil-Yong, Moore, John P., Subramaniam, Shankar, Khatri, Purvesh, Montefiori, David, Kozlowski, Pamela A., Derdeyn, Cynthia A., Hunter, Eric, Masopust, David, Amara, Rama R., Pulendran, Bali
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group US 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7303014/
https://ncbi.nlm.nih.gov/pubmed/32393800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41591-020-0858-8
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