Inhibition of G protein-gated K(+) channels by tertiapin-Q rescues sinus node dysfunction and atrioventricular conduction in mouse models of primary bradycardia

Sinus node (SAN) dysfunction (SND) manifests as low heart rate (HR) and is often accompanied by atrial tachycardia or atrioventricular (AV) block. The only currently available therapy for chronic SND is the implantation of an electronic pacemaker. Because of the growing burden of SND in the populati...

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Publicado en:Sci Rep
Autores principales: Bidaud, Isabelle, Chong, Antony Chung You, Carcouet, Agnes, Waard, Stephan De, Charpentier, Flavien, Ronjat, Michel, Waard, Michel De, Isbrandt, Dirk, Wickman, Kevin, Vincent, Anne, Mangoni, Matteo E., Mesirca, Pietro
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7300035/
https://ncbi.nlm.nih.gov/pubmed/32555258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-66673-8
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