G protein-gated I(KACh) channels as therapeutic targets for treatment of sick sinus syndrome and heart block

Dysfunction of pacemaker activity in the sinoatrial node (SAN) underlies “sick sinus” syndrome (SSS), a common clinical condition characterized by abnormally low heart rate (bradycardia). If untreated, SSS carries potentially life-threatening symptoms, such as syncope and end-stage organ hypoperfusi...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Mesirca, Pietro, Bidaud, Isabelle, Briec, François, Evain, Stéphane, Torrente, Angelo G., Le Quang, Khai, Leoni, Anne-Laure, Baudot, Matthias, Marger, Laurine, Chung You Chong, Antony, Nargeot, Joël, Striessnig, Joerg, Wickman, Kevin, Charpentier, Flavien, Mangoni, Matteo E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2016
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PNAS Plus
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4763776/
https://ncbi.nlm.nih.gov/pubmed/26831068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1517181113
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