Concomitant genetic ablation of L-type Ca(v)1.3 (α(1D)) and T-type Ca(v)3.1 (α(1G)) Ca(2+) channels disrupts heart automaticity

Cardiac automaticity is set by pacemaker activity of the sinus node (SAN). In addition to the ubiquitously expressed cardiac voltage-gated L-type Ca(v)1.2 Ca(2+) channel isoform, pacemaker cells within the SAN and the atrioventricular node co-express voltage-gated L-type Ca(v)1.3 and T-type Ca(v)3.1...

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Publicado no:Sci Rep
Main Authors: Baudot, Matthias, Torre, Eleonora, Bidaud, Isabelle, Louradour, Julien, Torrente, Angelo G., Fossier, Lucile, Talssi, Leïla, Nargeot, Joël, Barrère-Lemaire, Stéphanie, Mesirca, Pietro, Mangoni, Matteo E.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7642305/
https://ncbi.nlm.nih.gov/pubmed/33144668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-76049-7
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