Distinct localization and modulation of Ca(v)1.2 and Ca(v)1.3 L-type Ca(2+) channels in mouse sinoatrial node

Dysregulation of L-type Ca(2+) currents in sinoatrial nodal (SAN) cells causes cardiac arrhythmia. Both Ca(v)1.2 and Ca(v)1.3 channels mediate sinoatrial L-type currents. Whether these channels exhibit differences in modulation and localization, which could affect their contribution to pacemaking, i...

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Autors principals: Christel, Carl J, Cardona, Natalia, Mesirca, Pietro, Herrmann, Stefan, Hofmann, Franz, Striessnig, Joerg, Ludwig, Andreas, Mangoni, Matteo E, Lee, Amy
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Science Inc 2012
Matèries:
Cardiovascular
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533195/
https://ncbi.nlm.nih.gov/pubmed/23045342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2012.239954
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