Paradoxical Effect of Increased Diastolic Ca(2+) Release and Decreased Sinoatrial Node Activity in a Mouse Model of Catecholaminergic Polymorphic Ventricular Tachycardia

BACKGROUND: Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) is characterized by stress-triggered syncope and sudden death. CPVT patients manifest sino-atrial node (SAN) dysfunction, the mechanisms of which remain unexplored. METHODS AND RESULTS: We investigated SAN [Ca(2+)](i) handling...

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Detalhes bibliográficos
Main Authors: Neco, Patricia, Torrente, Angelo, Mesirca, Pietro, Zorio, Esther, Liu, Nian, Priori, Silvia G., Napolitano, Carlo, Richard, Sylvain, Benitah, Jean-Pierre, Mangoni, Matteo E., Gómez, Ana María
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3434373/
https://ncbi.nlm.nih.gov/pubmed/22711277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.111.075382
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