The G-protein–gated K(+) channel, I(KACh), is required for regulation of pacemaker activity and recovery of resting heart rate after sympathetic stimulation

Parasympathetic regulation of sinoatrial node (SAN) pacemaker activity modulates multiple ion channels to temper heart rate. The functional role of the G-protein–activated K(+) current (I(KACh)) in the control of SAN pacemaking and heart rate is not completely understood. We have investigated the fu...

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Main Authors: Mesirca, Pietro, Marger, Laurine, Toyoda, Futoshi, Rizzetto, Riccardo, Audoubert, Matthieu, Dubel, Stefan, Torrente, Angelo G., DiFrancesco, Mattia L., Muller, Jana Christina, Leoni, Anne-Laure, Couette, Brigitte, Nargeot, Joël, Clapham, David E., Wickman, Kevin, Mangoni, Matteo E.
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2013
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3727310/
https://ncbi.nlm.nih.gov/pubmed/23858001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201310996
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