Inhibition of G protein-gated K(+) channels by tertiapin-Q rescues sinus node dysfunction and atrioventricular conduction in mouse models of primary bradycardia

Sinus node (SAN) dysfunction (SND) manifests as low heart rate (HR) and is often accompanied by atrial tachycardia or atrioventricular (AV) block. The only currently available therapy for chronic SND is the implantation of an electronic pacemaker. Because of the growing burden of SND in the populati...

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Pubblicato in:Sci Rep
Autori principali: Bidaud, Isabelle, Chong, Antony Chung You, Carcouet, Agnes, Waard, Stephan De, Charpentier, Flavien, Ronjat, Michel, Waard, Michel De, Isbrandt, Dirk, Wickman, Kevin, Vincent, Anne, Mangoni, Matteo E., Mesirca, Pietro
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7300035/
https://ncbi.nlm.nih.gov/pubmed/32555258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-66673-8
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