Massively parallel single-cell chromatin landscapes of human immune cell development and intratumoral T cell exhaustion

Understanding complex tissues requires single-cell deconstruction of gene regulation with precision and scale. Here, we assess the performance of a massively parallel droplet-based method for mapping transposase-accessible chromatin in single cells using sequencing (scATAC-seq). We apply scATAC-seq...

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Pubblicato in:Nat Biotechnol
Autori principali: Satpathy, Ansuman T., Granja, Jeffrey M., Yost, Kathryn E., Qi, Yanyan, Meschi, Francesca, McDermott, Geoffrey P., Olsen, Brett N., Mumbach, Maxwell R., Pierce, Sarah E., Corces, M. Ryan, Shah, Preyas, Bell, Jason C., Jhutty, Darisha, Nemec, Corey M., Wang, Jean, Wang, Li, Yin, Yifeng, Giresi, Paul G., Chang, Anne Lynn S., Zheng, Grace X. Y., Greenleaf, William J., Chang, Howard Y.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7299161/
https://ncbi.nlm.nih.gov/pubmed/31375813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41587-019-0206-z
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