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Potential Contribution of Ryanodine Receptor 2 Upregulation to cGMP/PKG Signaling-induced Cone Degeneration in Cyclic Nucleotide-gated Channel Deficiency
Photoreceptor cyclic nucleotide-gated (CNG) channels regulate Ca(2+) influx in rod and cone photoreceptors. Mutations in cone CNG channel subunits CNGA3 and CNGB3 are associated with achromatopsia and cone dystrophies. Mice lacking functional cone CNG channel show endoplasmic reticulum (ER) stress-a...
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| Publicado no: | FASEB J |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7299158/ https://ncbi.nlm.nih.gov/pubmed/32173907 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201901951RR |
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