Endoplasmic Reticulum Stress-associated Cone Photoreceptor Degeneration in Cyclic Nucleotide-gated Channel Deficiency

Cyclic nucleotide-gated (CNG) channels play a pivotal role in phototransduction. Mutations in the cone CNG channel subunits CNGA3 and CNGB3 account for >70% of all known cases of achromatopsia. Cones degenerate in achromatopsia patients and in CNGA3(−/−) and CNGB3(−/−) mice. This work investigate...

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Hlavní autoři: Thapa, Arjun, Morris, Lynsie, Xu, Jianhua, Ma, Hongwei, Michalakis, Stylianos, Biel, Martin, Ding, Xi-Qin
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365688/
https://ncbi.nlm.nih.gov/pubmed/22493484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.342220
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