Endoplasmic reticulum (ER) Ca(2+)-channel activity contributes to ER stress and cone death in cyclic nucleotide-gated channel deficiency

Endoplasmic reticulum (ER) stress and mislocalization of improperly folded proteins have been shown to contribute to photoreceptor death in models of inherited retinal degenerative diseases. In particular, mice with cone cyclic nucleotide-gated (CNG) channel deficiency, a model for achromatopsia, di...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Butler, Michael R., Ma, Hongwei, Yang, Fan, Belcher, Joshua, Le, Yun-Zheng, Mikoshiba, Katsuhiko, Biel, Martin, Michalakis, Stylianos, Iuso, Anthony, Križaj, David, Ding, Xi-Qin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5500788/
https://ncbi.nlm.nih.gov/pubmed/28495882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.782326
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