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Endoplasmic reticulum (ER) Ca(2+)-channel activity contributes to ER stress and cone death in cyclic nucleotide-gated channel deficiency

Endoplasmic reticulum (ER) stress and mislocalization of improperly folded proteins have been shown to contribute to photoreceptor death in models of inherited retinal degenerative diseases. In particular, mice with cone cyclic nucleotide-gated (CNG) channel deficiency, a model for achromatopsia, di...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Butler, Michael R., Ma, Hongwei, Yang, Fan, Belcher, Joshua, Le, Yun-Zheng, Mikoshiba, Katsuhiko, Biel, Martin, Michalakis, Stylianos, Iuso, Anthony, Križaj, David, Ding, Xi-Qin
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5500788/
https://ncbi.nlm.nih.gov/pubmed/28495882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.782326
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