Endoplasmic reticulum (ER) Ca(2+)-channel activity contributes to ER stress and cone death in cyclic nucleotide-gated channel deficiency

Endoplasmic reticulum (ER) stress and mislocalization of improperly folded proteins have been shown to contribute to photoreceptor death in models of inherited retinal degenerative diseases. In particular, mice with cone cyclic nucleotide-gated (CNG) channel deficiency, a model for achromatopsia, di...

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Bibliografiska uppgifter
I publikationen:J Biol Chem
Huvudupphovsmän: Butler, Michael R., Ma, Hongwei, Yang, Fan, Belcher, Joshua, Le, Yun-Zheng, Mikoshiba, Katsuhiko, Biel, Martin, Michalakis, Stylianos, Iuso, Anthony, Križaj, David, Ding, Xi-Qin
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2017
Ämnen:
Molecular Bases of Disease
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5500788/
https://ncbi.nlm.nih.gov/pubmed/28495882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.782326
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