cGMP/Protein Kinase G Signaling Suppresses Inositol 1,4,5-Trisphosphate Receptor Phosphorylation and Promotes Endoplasmic Reticulum Stress in Photoreceptors of Cyclic Nucleotide-gated Channel-deficient Mice

Photoreceptor cyclic nucleotide-gated (CNG) channels play a pivotal role in phototransduction. Mutations in the cone CNG channel subunits CNGA3 and CNGB3 are associated with achromatopsia and cone dystrophies. We have shown endoplasmic reticulum (ER) stress-associated apoptotic cone death and increa...

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Vydáno v:J Biol Chem
Hlavní autoři: Ma, Hongwei, Butler, Michael R., Thapa, Arjun, Belcher, Josh, Yang, Fan, Baehr, Wolfgang, Biel, Martin, Michalakis, Stylianos, Ding, Xi-Qin
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2015
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4543649/
https://ncbi.nlm.nih.gov/pubmed/26124274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.641159
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