cGMP Accumulation Causes Photoreceptor Degeneration in CNG Channel Deficiency: Evidence of cGMP Cytotoxicity Independently of Enhanced CNG Channel Function

Photoreceptor cyclic nucleotide-gated (CNG) channels regulate Ca(2+) influx in rod and cone photoreceptors. cGMP, the native ligand of the photoreceptor CNG channels, has been associated with cytotoxicity when its levels rise above normal due to defects in photoreceptor phosphodiesterase (PDE6) or r...

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Main Authors: Xu, Jianhua, Morris, Lynsie, Thapa, Arjun, Ma, Hongwei, Michalakis, Stylianos, Biel, Martin, Baehr, Wolfgang, Peshenko, Igor V., Dizhoor, Alexander M., Ding, Xi-Qin
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3771030/
https://ncbi.nlm.nih.gov/pubmed/24027293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0909-13.2013
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