The cGMP-Dependent Protein Kinase 2 Contributes to Cone Photoreceptor Degeneration in the Cnga3-Deficient Mouse Model of Achromatopsia

Mutations in the CNGA3 gene, which encodes the A subunit of the cyclic guanosine monophosphate (cGMP)-gated cation channel in cone photoreceptor outer segments, cause total colour blindness, also referred to as achromatopsia. Cones lacking this channel protein are non-functional, accumulate high lev...

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Udgivet i:Int J Mol Sci
Main Authors: Koch, Mirja, Scheel, Constanze, Ma, Hongwei, Yang, Fan, Stadlmeier, Michael, Glück, Andrea F., Murenu, Elisa, Traube, Franziska R., Carell, Thomas, Biel, Martin, Ding, Xi-Qin, Michalakis, Stylianos
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7793084/
https://ncbi.nlm.nih.gov/pubmed/33374621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22010052
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