Vitreal delivery of AAV vectored Cnga3 restores cone function in CNGA3(−/−)/Nrl(−/−) mice, an all-cone model of CNGA3 achromatopsia(†)

The CNGA3(−/−)/Nrl(−/−) mouse is a cone-dominant model with Cnga3 channel deficiency, which partially mimics the all cone foveal structure of human achromatopsia 2 with CNGA3 mutations. Although subretinal (SR) AAV vector administration can transfect retinal cells efficiently, the injection-induced...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Hum Mol Genet
Autors principals: Du, Wei, Tao, Ye, Deng, Wen-Tao, Zhu, Ping, Li, Jie, Dai, Xufeng, Zhang, Yuxin, Shi, Wei, Liu, Xuan, Chiodo, Vince A., Ding, Xi-Qin, Zhao, Chen, Michalakis, Stylianos, Biel, Martin, Zhang, Zuoming, Qu, Jia, Hauswirth, William W., Pang, Ji-jing
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2015
Matèries:
Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4459390/
https://ncbi.nlm.nih.gov/pubmed/25855802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv114
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars