Restoration of Cone Vision in the CNGA3(−/−) Mouse Model of Congenital Complete Lack of Cone Photoreceptor Function

Congenital absence of cone photoreceptor function is associated with strongly impaired daylight vision and loss of color discrimination in human achromatopsia. Here, we introduce viral gene replacement therapy as a potential treatment for this disease in the CNGA3(−/−) mouse model. We show that such...

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Bibliografiske detaljer
Main Authors: Michalakis, Stylianos, Mühlfriedel, Regine, Tanimoto, Naoyuki, Krishnamoorthy, Vidhyasankar, Koch, Susanne, Fischer, M Dominik, Becirovic, Elvir, Bai, Lin, Huber, Gesine, Beck, Susanne C, Fahl, Edda, Büning, Hildegard, Paquet-Durand, François, Zong, Xiangang, Gollisch, Tim, Biel, Martin, Seeliger, Mathias W
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2010
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2997579/
https://ncbi.nlm.nih.gov/pubmed/20628362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.149
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