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Cyclin B1 scaffolds MAD1 at the kinetochore corona to activate the mitotic checkpoint
Cyclin B:CDK1 is the master kinase regulator of mitosis. We show here that, in addition to its kinase functions, mammalian Cyclin B also scaffolds a localised signalling pathway to help preserve genome stability. Cyclin B1 localises to an expanded region of the outer kinetochore, known as the corona...
Gorde:
| Argitaratua izan da: | EMBO J |
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| Egile Nagusiak: | , , , , , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
John Wiley and Sons Inc.
2020
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7298293/ https://ncbi.nlm.nih.gov/pubmed/32202322 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2019103180 |
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