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Cyclin B1 scaffolds MAD1 at the kinetochore corona to activate the mitotic checkpoint

Cyclin B:CDK1 is the master kinase regulator of mitosis. We show here that, in addition to its kinase functions, mammalian Cyclin B also scaffolds a localised signalling pathway to help preserve genome stability. Cyclin B1 localises to an expanded region of the outer kinetochore, known as the corona...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Allan, Lindsey A, Camacho Reis, Magda, Ciossani, Giuseppe, Huis in ‘t Veld, Pim J, Wohlgemuth, Sabine, Kops, Geert JPL, Musacchio, Andrea, Saurin, Adrian T
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7298293/
https://ncbi.nlm.nih.gov/pubmed/32202322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2019103180
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