A kinase-deficient NTRK2 splice variant predominates in glioma and amplifies several oncogenic signaling pathways

Independent scientific achievements have led to the discovery of aberrant splicing patterns in oncogenesis, while more recent advances have uncovered novel gene fusions involving neurotrophic tyrosine receptor kinases (NTRKs) in gliomas. The exploration of NTRK splice variants in normal and neoplast...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Pattwell, Siobhan S., Arora, Sonali, Cimino, Patrick J., Ozawa, Tatsuya, Szulzewsky, Frank, Hoellerbauer, Pia, Bonifert, Tobias, Hoffstrom, Benjamin G., Boiani, Norman E., Bolouri, Hamid, Correnti, Colin E., Oldrini, Barbara, Silber, John R., Squatrito, Massimo, Paddison, Patrick J., Holland, Eric C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7293284/
https://ncbi.nlm.nih.gov/pubmed/32532995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16786-5
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