A kinase-deficient NTRK2 splice variant predominates in glioma and amplifies several oncogenic signaling pathways

Independent scientific achievements have led to the discovery of aberrant splicing patterns in oncogenesis, while more recent advances have uncovered novel gene fusions involving neurotrophic tyrosine receptor kinases (NTRKs) in gliomas. The exploration of NTRK splice variants in normal and neoplast...

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Publicado no:Nat Commun
Main Authors: Pattwell, Siobhan S., Arora, Sonali, Cimino, Patrick J., Ozawa, Tatsuya, Szulzewsky, Frank, Hoellerbauer, Pia, Bonifert, Tobias, Hoffstrom, Benjamin G., Boiani, Norman E., Bolouri, Hamid, Correnti, Colin E., Oldrini, Barbara, Silber, John R., Squatrito, Massimo, Paddison, Patrick J., Holland, Eric C.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7293284/
https://ncbi.nlm.nih.gov/pubmed/32532995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16786-5
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