CBMT-38. THERAPEUTIC INHIBITION OF THE SPLICEOSOME IN GLIOBLASTOMA: CHANGES FORM MINOR TO MAJOR

Chemical or genetic perturbation of the spliceosome function may represent a therapeutic opportunity for Glioblastoma multiforme (GBM) and other cancers. We and others have shown that oncogenic MYC activity causes spliceosome vulnerability and leads to deficits in 3’ splice site recognition upon spl...

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Bibliografiska uppgifter
I publikationen:Neuro Oncol
Huvudupphovsmän: Bonifert, Tobias, Arora, Sonali, Fitzgibbon, Matthew, Paddison, Patrick
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2019
Ämnen:
Cell Biology and Metabolism
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847980/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.160
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