CBMT-30. TARGETING NICOTINAMIDE ADENINE DINUCLEOTIDE BIOSYNTHESIS IN CNS TUMORS

Nicotinamide adenine dinucleotide (NAD) metabolic pathways have been shown to be critical targets in many cancers, including brain tumors. However, inhibiting nicotinamide metabolism has had limited efficacy in the clinic to date due to on-target side effects. To identify new metabolic vulnerabiliti...

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Bibliografiska uppgifter
I publikationen:Neuro Oncol
Huvudupphovsmän: Lindsay, Ken, Brenner, Charles, Hockenbery, David, Paddison, Patrick
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2019
Ämnen:
Cell Biology and Metabolism
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847852/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.152
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