Quantification of the endogenous growth hormone and prolactin lowering effects of a somatostatin-dopamine chimera using population PK/PD modeling

A phase 1 clinical trial in healthy male volunteers was conducted with a somatostatin-dopamine chimera (BIM23B065), from which information could be obtained on the concentration-effect relationship of the inhibition of pulsatile endogenous growth hormone and prolactin secretion. Endogenous growth ho...

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Bibliographic Details
Published in:J Pharmacokinet Pharmacodyn
Main Authors: van Esdonk, Michiel J., Burggraaf, Jacobus, Dehez, Marion, van der Graaf, Piet H., Stevens, Jasper
Format: Artigo
Language:Inglês
Published: Springer US 2020
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Original Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7289785/
https://ncbi.nlm.nih.gov/pubmed/32248329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10928-020-09683-3
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