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A two-step deconvolution-analysis-informed population pharmacodynamic modeling approach for drugs targeting pulsatile endogenous compounds

Pharmacodynamic modeling of pulsatile endogenous compounds (e.g. growth hormone [GH]) is currently limited to the identification of a low number of pulses. Commonly used pharmacodynamic models are not able to capture the complexity of pulsatile secretion and therefore non-compartmental analyses are...

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Dettagli Bibliografici
Pubblicato in:J Pharmacokinet Pharmacodyn
Autori principali: van Esdonk, Michiel J., Burggraaf, Jacobus, van der Graaf, Piet H., Stevens, Jasper
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer US 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5514197/
https://ncbi.nlm.nih.gov/pubmed/28497294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10928-017-9526-0
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