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A two-step deconvolution-analysis-informed population pharmacodynamic modeling approach for drugs targeting pulsatile endogenous compounds
Pharmacodynamic modeling of pulsatile endogenous compounds (e.g. growth hormone [GH]) is currently limited to the identification of a low number of pulses. Commonly used pharmacodynamic models are not able to capture the complexity of pulsatile secretion and therefore non-compartmental analyses are...
Guardat en:
| Publicat a: | J Pharmacokinet Pharmacodyn |
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| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Springer US
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5514197/ https://ncbi.nlm.nih.gov/pubmed/28497294 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10928-017-9526-0 |
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