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How are growth hormone and insulin-like growth factor-1 reported as markers for drug effectiveness in clinical acromegaly research? A comprehensive methodologic review

OBJECTIVE: In rare disease research, most randomized prospective clinical trials can only use limited number of patients and are comprised of highly heterogeneous populations. Therefore, it is crucial to report the results in such a manner that it allows for comparison of treatment effectiveness and...

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Detalhes bibliográficos
Publicado no:Pituitary
Main Authors: van Esdonk, Michiel J., van Zutphen, Eline J. M., Roelfsema, Ferdinand, Pereira, Alberto M., van der Graaf, Piet H., Biermasz, Nienke R., Stevens, Jasper, Burggraaf, Jacobus
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5942341/
https://ncbi.nlm.nih.gov/pubmed/29605877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11102-018-0884-4
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