PK/PD modeling of 5‐hydroxytryptophan (5‐HTP) challenge test with cortisol measurement in serum and saliva

This research was planned to build a Pharmacokinetic/Pharmacodynamic (PK/PD) model of 5‐hydroxytryptophan (5‐HTP) challenge study including a circadian rhythm component of cortisol and to predict serum cortisol based on saliva cortisol. Data from three 5‐HTP challenge studies in healthy volunteers w...

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Bibliographic Details
Published in:Pharmacol Res Perspect
Main Authors: Guan, Zheng, Jacobs, Gabriel, van Pelt, Hans, Van Gerven, Joop M.A., Burggraaf, Jacobus, Zhao, Wei
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2020
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7069653/
https://ncbi.nlm.nih.gov/pubmed/32168433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.574
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