MYCN expression induces replication stress and sensitivity to PARP inhibition in neuroblastoma

This study investigates the influence expression of the MYCN oncogene has on the DNA damage response, replication fork progression and sensitivity to PARP inhibition in neuroblastoma. In a panel of neuroblastoma cell lines, MYCN amplification or MYCN expression resulted in increased cell death in re...

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Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: King, David, Li, Xiao Dun, Almeida, Gilberto S., Kwok, Colin, Gravells, Polly, Harrison, Daniel, Burke, Saoirse, Hallsworth, Albert, Jamin, Yann, George, Sally, Robinson, Simon P., Lord, Christopher J., Poon, Evon, Yeomanson, Daniel, Chesler, Louis, Bryant, Helen E.
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2020
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7289530/
https://ncbi.nlm.nih.gov/pubmed/32577161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.27329
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