MYCN expression induces replication stress and sensitivity to PARP inhibition in neuroblastoma

This study investigates the influence expression of the MYCN oncogene has on the DNA damage response, replication fork progression and sensitivity to PARP inhibition in neuroblastoma. In a panel of neuroblastoma cell lines, MYCN amplification or MYCN expression resulted in increased cell death in re...

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Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: King, David, Li, Xiao Dun, Almeida, Gilberto S., Kwok, Colin, Gravells, Polly, Harrison, Daniel, Burke, Saoirse, Hallsworth, Albert, Jamin, Yann, George, Sally, Robinson, Simon P., Lord, Christopher J., Poon, Evon, Yeomanson, Daniel, Chesler, Louis, Bryant, Helen E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2020
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7289530/
https://ncbi.nlm.nih.gov/pubmed/32577161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.27329
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