MYCN expression induces replication stress and sensitivity to PARP inhibition in neuroblastoma

This study investigates the influence expression of the MYCN oncogene has on the DNA damage response, replication fork progression and sensitivity to PARP inhibition in neuroblastoma. In a panel of neuroblastoma cell lines, MYCN amplification or MYCN expression resulted in increased cell death in re...

詳細記述

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書誌詳細
出版年:Oncotarget
主要な著者: King, David, Li, Xiao Dun, Almeida, Gilberto S., Kwok, Colin, Gravells, Polly, Harrison, Daniel, Burke, Saoirse, Hallsworth, Albert, Jamin, Yann, George, Sally, Robinson, Simon P., Lord, Christopher J., Poon, Evon, Yeomanson, Daniel, Chesler, Louis, Bryant, Helen E.
フォーマット: Artigo
言語:Inglês
出版事項: Impact Journals LLC 2020
主題:
Research Paper
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7289530/
https://ncbi.nlm.nih.gov/pubmed/32577161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.27329
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