The ALK(F1174L) mutation potentiates the oncogenic activity of MYCN in neuroblastoma

The ALK(F1174L) mutation is associated with intrinsic and acquired resistance to crizotinib and cosegregates with MYCN in neuroblastoma. In this study, we generated a mouse model overexpressing ALK(F1174L) in the neural crest. Compared to ALK(F1174L) and MYCN alone, coexpression of these two oncogen...

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Detalhes bibliográficos
Main Authors: Berry, Teeara, Luther, William, Bhatnagar, Namrata, Jamin, Yann, Poon, Evon, Sanda, Takaomi, Pei, Desheng, Sharma, Bandana, Vetharoy, Winston R., Hallsworth, Albert, Ahmad, Zai, Barker, Karen, Moreau, Lisa, Webber, Hannah, Wang, Wenchao, Liu, Qingsong, Perez-Atayde, Antonio, Rodig, Scott, Cheung, Nai-Kong, Raynaud, Florence, Hallberg, Bengt, Robinson, Simon P., Gray, Nathanael S., Pearson, Andrew D.J., Eccles, Suzanne A., Chesler, Louis, George, Rani E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3417812/
https://ncbi.nlm.nih.gov/pubmed/22789543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2012.06.001
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