Paradoxical mitotic exit induced by a small molecule inhibitor of APC/C(Cdc20)

The Anaphase Promoting Complex/Cyclosome (APC/C) is a ubiquitin ligase that initiates anaphase and mitotic exit. The APC/C is activated by Cdc20 and inhibited by the mitotic checkpoint complex (MCC), which delays mitotic exit when the spindle assembly checkpoint (SAC) is activated. We previously ide...

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Publicat a:Nat Chem Biol
Autors principals: Richeson, Katherine V., Bodrug, Tatyana, Sackton, Katharine L., Yamaguchi, Masaya, Paulo, Joao A., Gygi, Steven P., Schulman, Brenda A., Brown, Nicholas G., King, Randall W.
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7289404/
https://ncbi.nlm.nih.gov/pubmed/32152539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-020-0495-z
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