The clonal evolution of metastatic colorectal cancer

Tumor heterogeneity and evolution drive treatment resistance in metastatic colorectal cancer (mCRC). Patient-derived xenografts (PDXs) can model mCRC biology; however, their ability to accurately mimic human tumor heterogeneity is unclear. Current genomic studies in mCRC have limited scope and lack...

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Publicado en:Sci Adv
Main Authors: Dang, Ha X., Krasnick, Bradley A., White, Brian S., Grossman, Julie G., Strand, Matthew S., Zhang, Jin, Cabanski, Christopher R., Miller, Christopher A., Fulton, Robert S., Goedegebuure, S. Peter, Fronick, Catrina C., Griffith, Malachi, Larson, David E., Goetz, Brian D., Walker, Jason R., Hawkins, William G., Strasberg, Steven M., Linehan, David C., Lim, Kian H., Lockhart, A. Craig, Mardis, Elaine R., Wilson, Richard K., Ley, Timothy J., Maher, Christopher A., Fields, Ryan C.
Formato: Artigo
Idioma:Inglês
Publicado: American Association for the Advancement of Science 2020
Assuntos:
Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7286679/
https://ncbi.nlm.nih.gov/pubmed/32577507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aay9691
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