The clonal evolution of metastatic colorectal cancer

Tumor heterogeneity and evolution drive treatment resistance in metastatic colorectal cancer (mCRC). Patient-derived xenografts (PDXs) can model mCRC biology; however, their ability to accurately mimic human tumor heterogeneity is unclear. Current genomic studies in mCRC have limited scope and lack...

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Veröffentlicht in:Sci Adv
Hauptverfasser: Dang, Ha X., Krasnick, Bradley A., White, Brian S., Grossman, Julie G., Strand, Matthew S., Zhang, Jin, Cabanski, Christopher R., Miller, Christopher A., Fulton, Robert S., Goedegebuure, S. Peter, Fronick, Catrina C., Griffith, Malachi, Larson, David E., Goetz, Brian D., Walker, Jason R., Hawkins, William G., Strasberg, Steven M., Linehan, David C., Lim, Kian H., Lockhart, A. Craig, Mardis, Elaine R., Wilson, Richard K., Ley, Timothy J., Maher, Christopher A., Fields, Ryan C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Association for the Advancement of Science 2020
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Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7286679/
https://ncbi.nlm.nih.gov/pubmed/32577507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aay9691
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