Functional heterogeneity of genetically defined subclones in acute myeloid leukemia

The relationships between clonal architecture and functional heterogeneity in acute myeloid leukemia (AML) samples are not yet clear. We used targeted sequencing to track AML subclones identified by whole genome sequencing using a variety of experimental approaches. We found that virtually all AML s...

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Détails bibliographiques
Auteurs principaux: Klco, Jeffery M., Spencer, David H., Miller, Christopher A., Griffith, Malachi, Lamprecht, Tamara L., O’Laughlin, Michelle, Fronick, Catrina, Magrini, Vincent, Demeter, Ryan T., Fulton, Robert S., Eades, William C., Link, Daniel C., Graubert, Timothy A., Walter, Matthew J., Mardis, Elaine R., Dipersio, John F., Wilson, Richard K., Ley, Timothy J.
Format: Artigo
Langue:Inglês
Publié: 2014
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3983786/
https://ncbi.nlm.nih.gov/pubmed/24613412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2014.01.031
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