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Functional heterogeneity of genetically defined subclones in acute myeloid leukemia

The relationships between clonal architecture and functional heterogeneity in acute myeloid leukemia (AML) samples are not yet clear. We used targeted sequencing to track AML subclones identified by whole genome sequencing using a variety of experimental approaches. We found that virtually all AML s...

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Bibliografiska uppgifter
Huvudupphovsmän: Klco, Jeffery M., Spencer, David H., Miller, Christopher A., Griffith, Malachi, Lamprecht, Tamara L., O’Laughlin, Michelle, Fronick, Catrina, Magrini, Vincent, Demeter, Ryan T., Fulton, Robert S., Eades, William C., Link, Daniel C., Graubert, Timothy A., Walter, Matthew J., Mardis, Elaine R., Dipersio, John F., Wilson, Richard K., Ley, Timothy J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3983786/
https://ncbi.nlm.nih.gov/pubmed/24613412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2014.01.031
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