Subclones dominate at MDS progression following allogeneic hematopoietic cell transplant

Allogeneic hematopoietic cell transplantation (alloHCT) is a potentially curative treatment for myelodysplastic syndromes (MDS), but patients who relapse after transplant have poor outcomes. In order to understand the contribution of tumor clonal evolution to disease progression,we applied exome and...

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Udgivet i:JCI Insight
Main Authors: Jacoby, Meagan A., Duncavage, Eric J., Chang, Gue Su, Miller, Christopher A., Shao, Jin, Elliott, Kevin, Robinson, Joshua, Fulton, Robert S., Fronick, Catrina C., O’Laughlin, Michelle, Heath, Sharon E., Pusic, Iskra, Welch, John S., Link, Daniel C., DiPersio, John F., Westervelt, Peter, Ley, Timothy J., Graubert, Timothy A., Walter, Matthew J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5922277/
https://ncbi.nlm.nih.gov/pubmed/29515031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.98962
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