Dynamic Changes in the Clonal Structure of MDS and AML in Response to Epigenetic Therapy

Traditional response criteria in MDS and AML are based on bone marrow morphology and may not accurately reflect clonal tumor burden in patients treated with non-cytotoxic chemotherapy. We used next-generation sequencing of serial bone marrow samples to monitor MDS and AML tumor burden during treatme...

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Pubblicato in:Leukemia
Autori principali: Uy, Geoffrey L., Duncavage, Eric J., Chang, Gue Su, Jacoby, Meagan A., Miller, Christopher A., Shao, Jin, Heath, Sharon, Elliott, Kevin, Reinick, Teresa, Fulton, Robert S., Fronick, Catrina C., O’Laughlin, Michelle, Ganel, Liron, Abboud, Camille N., Cashen, Amanda F., DiPersio, John F., Wilson, Richard K, Link, Daniel C., Welch, John S., Ley, Timothy J., Graubert, Timothy A., Westervelt, Peter, Walter, Matthew J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5382101/
https://ncbi.nlm.nih.gov/pubmed/27740633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2016.282
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