The Tripartite Interaction of Phosphate, Autophagy and αKlotho in Health Maintenance

Aging-related organ degeneration is driven by multiple factors including the cell maintenance mechanisms of autophagy, the cytoprotective protein αKlotho, and the lesser known effects of excess phosphate (Pi), or phosphotoxicity. To examine the interplay between Pi, autophagy, and αKlotho, we used t...

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Pubblicato in:FASEB J
Autori principali: Shi, Mingjun, Maique, Jenny, Shaffer, Joy, Davidson, Taylor, Sebti, Salwa, Fernández, Álvaro F., Zou, Zhongju, Yan, Shirley, Levine, Beth, Moe, Orson W., Hu, Ming Chang
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7286356/
https://ncbi.nlm.nih.gov/pubmed/31908069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201902127R
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