The Tripartite Interaction of Phosphate, Autophagy and αKlotho in Health Maintenance

Aging-related organ degeneration is driven by multiple factors including the cell maintenance mechanisms of autophagy, the cytoprotective protein αKlotho, and the lesser known effects of excess phosphate (Pi), or phosphotoxicity. To examine the interplay between Pi, autophagy, and αKlotho, we used t...

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Gepubliceerd in:FASEB J
Hoofdauteurs: Shi, Mingjun, Maique, Jenny, Shaffer, Joy, Davidson, Taylor, Sebti, Salwa, Fernández, Álvaro F., Zou, Zhongju, Yan, Shirley, Levine, Beth, Moe, Orson W., Hu, Ming Chang
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7286356/
https://ncbi.nlm.nih.gov/pubmed/31908069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201902127R
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