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Glucocorticoids can induce BIM to trigger apoptosis in the absence of BAX and BAK1
Cells from two murine lymphoid lines died 24–48 h after treatment with the glucocorticoid dexamethasone. Deletion of Bax and Bak1 prevented rapid apoptosis, but treatment with dexamethasone for greater 6 days still led to cell death that was characterized by release of cytochrome c into the cytosol,...
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| Опубликовано в: : | Cell Death Dis |
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| Главные авторы: | , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group UK
2020
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7280233/ https://ncbi.nlm.nih.gov/pubmed/32513923 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-2599-5 |
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